MMJDirect Canada has long valued cannabis for its diverse properties. A defining characteristic of all cannabis plants is the array of substances known as cannabinoids or phytocannabinoids.
Current biomechanics research and studies on the therapeutic effects of these compounds are fueling the development of various applications for these plants and offering hope for those seeking relief from their symptoms.
Let’s dive deeper into the components of the plant and consider options for accessing cannabis if you want to explore its potential benefits.
Table of Contents
Key Takeaways:
- The cannabis plant contains substances like cannabinoids, terpenes, and flavonoids.
- The harmonious interaction of the compounds within the cannabis plant leads to a remarkable phenomenon known as the entourage effect.
- Full-spectrum cannabis extracts can provide greater medical benefits compared to isolated components of the plant.
The Cannabis Plants and Its Major Components
Cannabis, part of the Cannabaceae family along with hops, is characterized by secondary substances known as cannabinoids or phytocannabinoids. More than 150 cannabinoids are present, along with terpenoids, flavonoids, and alkaloids.
Cannabinoids
Cannabinoids are the naturally occurring compounds found in the cannabis plant, primarily on flower buds. Known as phytocannabinoids due to their botanical origins, they play a crucial role in the plant’s composition. Among the many phytocannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most recognized and researched.
Terpenes
Terpenes are aromatic compounds that significantly enhance the flavor and aroma of cannabis. They are not unique to cannabis; rather, they are found in nearly all plant life.
Within cannabis alone, over 140 terpenes have been identified, each contributing its own unique characteristics. Among these, some terpenes are exclusive to cannabis, enhancing its sensory profile. MMJDirect Canada identifies B-myrcene as the most prevalent terpene in cannabis, followed by trans-caryophyllene and a-pinene.
Flavonoids
Flavonoids are natural compounds found in fruits, vegetables, flowers, and more, responsible for their vibrant colors. In cannabis, flavonoids work alongside terpenes and cannabinoids. They show anti-inflammatory and neuroprotective properties, with compounds like apigenin exhibiting anxiolytic traits, while cannaflavins A and B have strong anti-inflammatory effects.
Molecules Journal: Exploring the Combined Components of Cannabis and Its Impact on Therapeutic Benefits
According to NORML, scientists have published over 32,000 marijuana studies in the last decade. Much of this research has focused on the effects of cannabis consumption, often overlooking other components like cannabinoids, terpenes, and flavonoids, with the literature primarily centered on the major cannabinoids THC and CBD.
The journal Molecules delves into the collaborative interactions among different chemical compounds in marijuana. It emphasizes the importance of understanding how these components work together to appreciate cannabis’s therapeutic potential fully.
Understanding the Significance of the Endocannabinoid System
The endocannabinoid system (ECS) regulates various physiological processes within the nervous system, with dysregulation linked to multiple pathological conditions. Therapeutic interventions targeting ECS activity have shown promise in managing medical issues related to neuroinflammation. The ECS consists of a complex network of receptors, endocannabinoids derived from arachidonic acid, receptor ligands, and enzymes responsible for endocannabinoid metabolism.
The ECS, featuring endocannabinoids like anandamide and 2-arachidonoylglycerol, and enzymes for their synthesis and breakdown, alongside cannabinoid receptors CB1 and CB2, is one of the most widespread signaling systems in the brain. Its impact extends to regulating stress response, anxiety, memory, pain perception, and motivated behavior. Endocannabinoid signaling is key to the development and maturation of neural circuits during adolescence.
The Entourage Effect of Cannabis Components within the ECS
The entourage effect is a pharmacological phenomenon showing how interactions among co-existing metabolites can modify the properties of individual molecules, regardless of their inherent pharmacological activity.
Preclinical research published in Molecules Journal (2019) and Oncotarget Journal (2020) highlights the relationship between phytocannabinoids and terpenes. These studies suggest that the therapeutic benefits of full-spectrum cannabis extracts, compared to isolated compounds, may arise from the entourage effect.
Cannabinoids
Research from the British Journal of Pharmacology and Multiple Sclerosis and Related Disorders has noted the suppressive effect of combined THC and CBD on neuroinflammation in animal models of multiple sclerosis. Phytocannabinoids exhibit immunomodulatory and anti-inflammatory properties. For example, in tests on LPS-activated microglial cells, THC and CBD showcased different mechanisms of action, with THC affecting the IFNβ pathway and CBD inhibiting the NF-κB-dependent pathway.
Terpenes
A study by Cheng et al. (2014) in the Journal of Pharmacology found that β-caryophyllene, a type of terpene, tends to bind to CB2R receptors. This may contribute to the combined effects of various phytochemicals in C. sativa, aiding in alleviating neurotoxicity associated with Alzheimer’s disease (AD).
Myrcene’s ability to enhance delta-9-THC transportation across the blood-brain barrier presents an intriguing avenue for developing AD therapeutics that can effectively target the central nervous system.
Flavonoids
Flavonoids may help address oxidative stress and neurodegeneration, enhancing the neuroprotective properties associated with the entourage effect. A comprehensive review in the journal Frontiers in Aging Neuroscience highlighted the neuroprotective benefits of various flavonoids, demonstrating their potential to reduce neuroinflammation and mitigate neurodegenerative processes.
The Authors Take
Understanding the intricate interplay between cannabinoids, terpenes, and flavonoids is crucial for realizing the full therapeutic benefits of cannabis, as emphasized by the authors in their study. They also identify essential evidence gaps that need immediate attention.
- Investigating the synergistic effects and mechanisms of cannabinoids, terpenes, and flavonoids requires focused research.
- Understanding cannabis phytochemical production and accumulation, especially under different lighting conditions, is vital for advancing medicinal applications.
- Comprehensive phytochemical profiling of cannabis strains, including their unique cannabinoid, terpene, and flavonoid ratios, holds potential for refining treatment strategies and developing personalized medicinal interventions.
Where to Buy Weed?
If you’re interested in exploring the health benefits of cannabis but unsure where to start, mail-order marijuana services and same-day cannabis delivery offer convenient ways to access cannabis products. These platforms provide a user-friendly website, allowing you to browse various marijuana products from the comfort of your home.
Buying cannabis online not only gives you access to affordable options and discounts but also helps you find high-quality cannabis products that suit your preferences.
Conclusion
Cannabis contains various compounds, each capable of producing unique effects. The synergy among these compounds enhances their therapeutic potential. Research, including studies featured in the Molecules journal, provides valuable insights into cannabis mechanisms, highlighting the importance of full-spectrum products for managing symptoms in specific conditions. While further targeted studies are needed, preliminary findings offer promising glimpses into potential and understanding.
Frequently Asked Questions
How much does it cost to buy cannabis online in Canada?
Cannabis prices per gram are notably more affordable in Canada compared to the US. In physical dispensaries, the price range for a gram is typically between $10 to $12, while online dispensaries often offer options starting at $2 per gram. A gram of cannabis can typically be around $5 for satisfactory quality, which corresponds to the AA+ to AAA grade range.
Can medical and recreational marijuana differ in price?
Cannabis can be used for either medical or recreational purposes, with medical cannabis generally being less expensive than recreational varieties. Medical cannabis costs may be eligible for tax deductions, and in some cases, insurance coverage might help offset expenses.
Are other marijuana products as affordable as cannabis flower?
The cost of purchasing cannabis online is lower than traditional sources. Alternative products like edibles, capsules, and oils may have slightly higher prices but remain within reasonable limits. Online dispensaries strive to maintain competitive pricing within the cannabis industry.
Is bulk cannabis cheaper than per gram?
Yes, buying cannabis in bulk often provides discounts compared to purchasing per gram. This is especially beneficial for frequent users or medical patients. Buying per gram allows for initial experimentation with its effects.
Does cheap cannabis mean low quality?
Price can be an indicator of cannabis quality, but it is not the sole factor. While many believe that inexpensive cannabis indicates inferior quality, this isn’t always true. It may simply be a batch nearing expiration, prompting dispensaries to reduce the price for timely sale. Judging cannabis solely on price can overlook factors that contribute to its overall value and experience.
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