Cannabis has historically been viewed with stigma due to its effects, but it is now receiving heightened recognition for its potential in various medical fields. Recent years have showcased a significant uptick in research focused on the therapeutic properties of cannabis, especially its advantages for neurological conditions.
In addition to its well-known benefits for stress relief, depression alleviation, and sleep improvement, cannabis shows promise in treating a wide range of neurological disorders. This article explores five such conditions and investigates how cannabis or cannabis contributes to their therapeutic applications.
Table of Contents
Key Takeaways:
- Certain cannabinoids and terpenes exhibit distinct effects on various neurological disorders.
- Linalool, myrcene, and limonene possess anti-convulsant properties.
- Equal ratios of THC and CBD, along with other cannabis compounds, may aid in cancer treatment.
A Natural Approach to Managing Neurological Disorders
Strategies for addressing the complexities of conditions such as Alzheimer’s disease (AD), brain tumors, Parkinson’s disease (PD), intractable epilepsy, and chronic traumatic encephalopathy (CTE) or traumatic brain injury (TBI) vary according to individual patient needs and the severity of their conditions.
Cannabis is a Viable Treatment Option
Epilepsy
The endocannabinoid system plays a crucial role in regulating seizure thresholds. THC, in particular, can effectively halt seizures, unlike traditional medications such as phenobarbital and diphenylhydantoin. Research has demonstrated acute spikes in endocannabinoid production and a sustained increase in CB1 production over time. The anti-convulsant properties of cannabinoids have been noted even at sedation levels.
THC, THCA, and linalool, a terpenoid found in cannabis, have been subjects of scientific examination. The debate surrounding THCA is intricate, with discussions about its CB1 activity versus its conversion to THC.
Recent studies also highlight the anti-convulsant properties of cannabidiolic acid (CBDA), suggesting its serotonergic effects. CBDA exhibits a notably higher affinity for the 5-HT1A receptor compared to CBD.
If you are interested in exploring cannabis vape pens for your condition, look for products that contain THC, CBD, THCA, or linalool.
Brain Tumours
Numerous studies have investigated the use of cannabis in patients diagnosed with brain tumors. A notable study published in the British Journal of Cancer in 2006 found that direct THC administration into tumors in patients with glioblastoma multiforme (GBM) slightly extended their life expectancy in nine cases.
Additionally, a case report from the Journal of Child’s Nervous System detailed complete regression of residual tumors in two children with pilocytic astrocytomas after using cannabis.
As a peroxisome proliferator-activated receptor-gamma (PPARγ) agonist, THCA may outperform CBDA, CBD, or THC in potential impacts. PPARs function as ligand-binding transcription factors, offering the promise of selectively targeting cancer cells while sparing normal cells. The synergistic effects of THCA with other cytotoxic agents underscore its potential in cancer therapy.
Equal concentrations of THC and CBD, when combined with THCA, CBDA, and terpenoids like limonene, hold promise for cancer treatment, as indicated by a study in the Planta Medicine Journal. Disposable cannabis pens can encapsulate these cannabinoids and terpenes in a single cartridge.
Parkinson’s Disease
An observational study revealed that 22 out of 28 participants tolerated smoked cannabis, presumably THC-predominant. The study also highlighted immediate benefits, including reductions in tremor, rigidity, and bradykinesia among participants.
In Parkinson’s disease, the loss of cells in the substantia nigra leads to widespread pathology over time. Tau proteins, which support the cytoskeleton and assist with axonal transport in neurons, undergo alterations that result in the formation of neurofibrillary tangles.
Nabiximols, a cannabis-based oral spray, significantly reduced tangles when administered to parkin-null mice expressing human tau. This treatment improved dopamine metabolism and glial function, while decreasing oxidative stress levels.
THC vape pens like cannabis can be an excellent option if you seek to improve tremors.
Alzheimer’s Disease
Alzheimer’s disease (AD) involves the formation of senile plaques from β-amyloid (Aβ) proteins, which develop when enzymes cleave a precursor protein (APP). Additionally, neurofibrillary tangles form from tau proteins with excessive phosphate groups attached. Occasionally, these tangles manifest before the β-amyloid plaques. Once initiated, the disease’s progression is relentless.
CBD acts as a protective antioxidant for the brain, safely interacting with NMDA receptors. It combats Alzheimer’s disease by halting Aβ plaque formation, reducing harmful ROS production, and preventing damage to fats in PC12 cells exposed to Aβ. Furthermore, CBD inhibits tau proteins from accumulating excessive phosphate groups on PC12 neurons affected by Aβ.
A study administered THC-predominant (2.5–30 mg/dose), CBD-predominant, and THCA primarily through tinctures and confections. Patients experienced reduced dependency on neuroleptic drugs, alleviated agitation, increased appetite, managed aggression, improved sleep quality, elevated mood, decreased nursing care demands, mitigated self-harm tendencies, and controlled pain.
Cannabis components show the potential to address various symptoms associated with this complex disorder:
- THC, CBD, and linalool may relieve agitation.
- Psychosis symptoms may respond well to CBD.
- THC and linalool could alleviate insomnia and restlessness.
- THC is noted for anorexia, while THC, CBD, and linalool may assist with aggression.
- THC, limonene, and CBD could potentially help manage depression.
- THC and CBD are recognized for pain relief.
- Alpha-pinene, alongside THC, is linked to memory enhancement.
- CBD and THC are associated with neuroprotection, while THC, CBD, and THCA may help reduce Aβ plaque formation.
Traumatic Brain Injury / Chronic Traumatic Encephalopathy
Cannabis, particularly strains combining THC and CBD, can alleviate symptoms associated with CTE, such as headaches, nausea, insomnia, dizziness, agitation, substance abuse, and psychotic symptoms.
A 2019 study indicated that varying THC and CBD concentrations help alleviate stress, agitation, depression, and anxiety—common emotional responses in chronic traumatic encephalopathy cases. Cannabinoids mitigate glutamate excitotoxicity, a process leading to nerve cell damage following a traumatic brain injury.
Want to Use cannabis for Your Current Condition?
Engaging in cannabis use is a widely accepted method to harness its benefits. If you aim to avoid the potential health risks associated with traditional methods, cannabis vapes offer a viable alternative.
MMJDirect Canada provides a range of options to help you select the best vape pen for your needs. You can choose based on the pen type, including disposable vape pens, and whether you prefer Sativa-dominant or Indica-dominant cartridges with high THC or specific concentrates.
Weed Vape Pens Treat Your Condition
Progress is essential in neurological treatment for the conditions discussed in this article. However, innovative approaches like using cannabis, including through a cannabis pen, within treatment protocols show promise. Research studies and anecdotal evidence suggest that cannabis, with its varying levels of THC, CBD, and other compounds, can interact with the ECS to help manage symptoms of these conditions.
Frequently Asked Questions
Can a dab pen provide the same experience as a vape pen?
A dab pen and a vape pen both vaporize cannabis concentrates but differ in intensity and usage. Dab pens cater to solid concentrates like wax, yielding a more intense effect, while vape pens utilize liquid concentrates, offering a milder, more controlled experience.
Are THC pens cheap?
The average cost of a cannabis pen is approximately $50. You can find options as economical as $20 and others reaching $200 or more. The price variation depends on battery life and the range of features offered.
Can my current medication interact with the active ingredient in my cannabis vape?
This depends on your prescription drug. If you take antidepressants while managing Parkinson’s disease, cannabis might lead to an initial surplus of serotonin, heightening the body’s reliance on these substances, potentially exacerbating depression and anxiety over time. It is advisable to consult your doctor before incorporating cannabis into your current medication regimen.
Are cannabis pens the best alternative when treating health issues with cannabis?
Weed pens provide a cleaner method to use cannabis without the smoke from combustion, making them a popular choice for individuals seeking a less harmful and discreet option for addressing health issues like pain and anxiety.
However, whether cannabis pens are the best choice can vary among users. Given the ongoing research into their long-term effects, it is crucial for anyone considering their use for health reasons to consult with a doctor first. This ensures they select the most suitable method for their health needs.
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